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doi: 10.1007/s00394-020-02188-2 42
Be Cautious With Effective at a Lower Dose A formulation may produce higher blood exposure in a pharmacokinetic study, but that does not automatically establish that a lower dose produces the same clinical result
A polyphenol-rich cranberry extract protects from diet-induced obesity, insulin resistance and intestinal inflammation in association with increased Akkermansia spp
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So again, theres a molecular basis for the additive increased efficacy without worsening of the side effect profile
