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This family, including ChaC1 and ChaC2, directly breaks down GSH within the cell into Cys-Gly and 5-oxoproline (11,20)

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These observations support the notion that GPR40 activation may interfere with inflammatory responses, regulating NLRP3 expression, and this effect might contribute to a reduction in -syn aggregation, thus limiting DA neuronal damage

Two registered trials exist: a Phase 1 safety and pharmacokinetics study (NCT02637284) with no posted results, and a Phase 2 hamstring-strain trial (NCT07437547) still recruiting