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According to the MHRA Summary of Product Characteristics, additional contraceptive precautions (such as barrier methods or non-oral contraception) are recommended for 4 weeks after starting tirzepatide and for 4 weeks after each dose increase

Encourage diet sources of B where possible, and adherence to the injection schedule.

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The 4 mm needle is long enough to traverse the skin and reach the subcutaneous tissue with minimal risk of intramuscular or intradermal penetration

For general background on how investigational peptides are evaluated for safety, the National Institutes of Healths overview of how experimental compounds move through clinical evaluation illustrates why oversight matters at every stage