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& Siegers, C

Fills for GLP1-s more than doubled even though insurance coverage for the off-label use is limited

Frontiers in medicine , 10 , 1124275

This structural optimization led to the identification of Compound 32 , a highly potent indane derivative with improved PDE1B inhibitory activity (PDE1B IC 50 : 2.4 nM) (Figure 10)