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This systemic inflammation can undermine the structural integrity of the bloodbrain barrier (BBB), making it more permeable by disrupting tight junction proteins such as ZO-1 and occludin [23]

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Another study in 311 patients with kidney stone disease evaluated magnesium levels in urine, a known marker of dietary intake of magnesium

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Nonetheless, the underlying reasons for the inconsistencies in the reported associations between T2DM and levels of plasma DPP-4 activity (lower, unaltered, higher) have not been adequately explained, although one study did suggest that it might be related to the populations studied, with changes only becoming evident once moderate or severe hyperglycaemia becomes established (68)

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