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There is a theoretical concern that very high doses may interfere with certain chemotherapy drugs that rely on oxidative mechanisms, so individuals undergoing cancer care should consult their oncologist before supplementing
We conducted searches using the following search terms: cisplatin, cancer, cisplatin nephrotoxicity, acute kidney injury, cisplatin-induced AKI, autophagy, AMPK-mTOR-mediated autophagy, necroptosis, RIPK1/RIPK3/MLKL-mediated necroptosis, necroinflammation, nephroprotective, autophagy activators, and necroptosis inhibitors
The donation of SAM's methyl group reduces it to SAM-e (S-adenosylmethionine), which reforms homocysteine, and the cycle begins again
Citations Citations to this article as recorded by Flavonoid-rich extracts of Nelumbo nucifera leaves alleviate obesity in HFD-fed mice via microbiota-dependent modulation of brown fat thermogenesis Zhenyu Wang, Xiangwen Ren, Zhihanxin Peng, Maomao Zeng, Zhaojun Wang, Qiuming Chen, Jie Chen, Xianjun Dai, Mark Christian, Xuejiao Qie, Zhiyong He Journal of Ethnopharmacology.2026
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