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In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist
Here are the directions generating the most clinical interest as we move through 2026: Gut-Brain Axis Applications Emerging research is exploring BPC-157s role in modulating the gut-brain axis the bidirectional communication network between the gastrointestinal system and the central nervous system
B.Reske-NielsenC.MithalP.IsacsonO
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Biomolecules 9 (11), 711
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