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When drugs did emerge, the story was predictable: an early wave of excitement followed by disappointment, safety scandals, or regulatory withdrawal

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Similarly, coronary artery disease patients with single, double, or triple-vessel stenosis and patients with acute coronary syndrome had a significant increase in malondialdehyde levels and the percentage of malondialdehyde release, associated with a marked decrease in GSH concentration, total antioxidant capacity and erythrocyte GSH peroxidase activity compared with controls (154)

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