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These therapies are especially helpful when used alongside testosterone replacement therapy and GLP-1 medications like semaglutide (Ozempic) or tirzepatide (Zepbound)

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doi: 10.1016/j.biopha.2018.08.135 31 HeshmatiJMoiniASepidarkishMMorvaridzadehMSalehiMPalmowskiAet al

CstB crystal structure predicts the role of the active-site loop The human PDO, ETHE1, has a strong preference towards glutathione persulfide (GSSH) as the substrate and has no detectable or minimal activity against other persulfides such as cysteine persulfide (CSSH), homocysteine persulfide, and CoA persulfide (CoASSH) 20, 30

Marini F, Studeny M, Dembinski J, Kidd S, Spaeth E, Zeng Z, Ling X, Klopp A, Lang F, Hall B, Andreeff M