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Conversely, FXR activation can ameliorate steatohepatitis and fibrosis by dynamically regulating lipid and glucose homeostasis in the NASH liver through cytokine-mediated mechanisms (Fiorucci et al., 2020)

Interestingly, DA may also directly inhibit mitochondrial respiration [103] and DA oxidation generates toxic quinones and ROS leading to mitochondrial dysfunction [104]

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1. Tear packet at the notches 2. Squeeze the entire contents of