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Secretion of pro-inflammatory cytokines (IL-6, IL-12, and TNF-) from macrophages was significantly inhibited by ARA-290

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While the canonical signalling pathway engaged upon MCR activation is the increase in cyclic-AMP, it was found that inhibition of human lung fibroblast proliferation and differentiation by Gs-coupled receptors is not predicted by the magnitude of cAMP response (176), suggesting that the involvement of other pathways should be investigated to understand these actions

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