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Unlike the original diabetic patient population, many off-label users are younger, healthier individuals without the metabolic dysfunction that might warrant acceptance of serious side effect risks

Do not use if you have Lebers disease (a rare eye disorder) because high-dose B12 can damage your optic nerve

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Salehi-Sahlabadi A, Varkaneh HK, Shahdadian F, et al

Geographically, the proportion of consumers reporting taste challenges varied significantly: United Kingdom 65.2% Germany 53.3% Brazil 37.2% Thailand 23.7% United States 20.3% Italy 15.1% These differences highlight how cultural eating habits or dietary preferences may interact with sensory perception