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Effects manifest gradually : Weeks 1-2 : better energy during workouts, less post-workout fatigue Weeks 2-4 : improved recovery, first signs on waist circumference Weeks 4-8 : measurable improvement in endurance and fat loss Weeks 8-12 : full effects on body composition and performance Muscle saturation takes several weeks, which is why long-term courses are important (8-12 weeks minimum)

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PMID: 8473389

Notably, studies in mice demonstrate that GLP-1R agonists specifically localize to and require arginine vasopressin neurons in the PVN to exert their hypophagic and weight-reducing effects, a process that is amplified by GIPR co-activation [81]