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Canadian-specific trials are not always required if sufficient international data exists

Smaller, more frequent meals may be better tolerated than large portions, especially during the initial titration phase when side effects are most common

Pak Vet J 41:142146 Sivaprasad R, Nagaraj M, Varalakshmi P (2004) Combined efficacies of lipoic acid and 2, 3-dimercaptosuccinic acid against lead-induced lipid peroxidation in rat liver

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