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10.3389/fphar.2012.00119 Front Pharmacol

Technical Comparison of Three Molecules Semaglutide Fatty acid side chain modification Strong albumin binding Weekly formulation paradigm Tirzepatide Dual-target synergy GIP/GLP-1 dual agonism Maximized synergistic effects Retatrutide Triple agonist design Multi-target system regulation New generation long-acting solution Technology Evolution Trends Single-target Dual-target Multi-target Long-acting Synergistic Systematic Weekly dosing Personalized dosing Precision regulation Discussion Question Among these three different technological paths, which one are you most optimistic about for future development

Front Neurosci (2019) 13:1112

Pinnen F, Cacciatore I, Cornacchia C, Sozio P, Iannitelli A, Costa M, et al