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Here, we investigate a diverse panel of 12 immunomodulatory drugs as host-directed treatments (HDTs) for TB meningitis utilizing a cross-species framework comprising studies in a mouse model of TB meningitis with clinical endpoints, and parallel mechanistic studies in a newly developed immune-vascularized human brain organoid model of TB meningitis and peripheral blood mononuclear cells (PBMCs) from patients with TB meningitis
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Less chewing and less oral stimulation: Appetite suppression reduces eating and chewing, and that lowers the mechanical triggers that stimulate saliva flow
Ossenkoppele R, Pichet Binette A, Groot C, Smith R, Strandberg O, Palmqvist S, et al
The practical promise is once-daily appetite support that sits between transient food signals and the multi-day pharmacokinetics of injectable drugs
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