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Hypertension 56 (4), 728733
It has a trans-3-hexenoic acid moiety at the N terminus which makes it resistant to enzymatic degradation, by dipeptidyl peptidases in particular
Research shows that berberine can help improve insulin sensitivity, which is crucial for maintaining healthy blood sugar levels
Additional information Peer review information Nature Reviews Endocrinology thanks G
Finally, it is worth noting that other metabolic intermadiates or biochemical molecules may accumulate in cancer cells [37], thus emerging as other possible oncometabolites, hence maintaing open the inclusion in this class of pro-cancer molecules
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