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Essentially, they function as GLP-1 analogs, mimicking the action of GLP-1 in the body
Groves HT, Cuthbertson L, James P, et al
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To overcome the rapid degradation of GLP-1, two approaches have been developed: 1) GLP-1 receptor agonists resistant to DPP-IV metabolism, and 2) DPP-IV inhibitors to augment the effect of native/endogenous GLP-1
Howard AD, Feighner SD, Cully DF, et al
(5) These conflicting findings suggest further research is needed for clarification
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