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An 8.7% reduction exceeds what most lifestyle interventions achieve
Smoking Nicotine increases oxidative stress and reduces glutathione levels in cells, weakening its therapeutic effect
Shigeoka T, Nomiyama T, Kawanami T, Hamaguchi Y, Horikawa T, Tanaka T, et al
[2] Diuretics also directly increase urine output
Nausea occurs in approximately 15-20% of patients and represents the most common side effect, typically emerging during dose escalation and often diminishing over several weeks as tolerance develops
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