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JANUMET is contraindicated in patients with an eGFR below 30 mL/min/1.73 m2 [see Contraindications (4)]
Conversely, those with lower-response markers benefit from progressing to 1.7 mg and potentially combining semaglutide with tirzepatide (a dual GLP-1/GIP agonist) for synergistic effect
The comparison between phentermine and semaglutide , phentermine and tirzepatide , and phentermine and GLP-1 medications broadly consistently shows the GLP-1 class producing greater weight loss with a more favorable long-term safety profile
The FDA has signed off on the first generic GLP-1 drug for weight loss
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