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doi:10.3389/fendo.2020.00178 Lo CWH, Fei Y, Cheung BMY
The effects of these medications on food-related reward pathways and impulse control in BED are largely theoretical and require further investigation through well-designed clinical trials
Finally, while Gilead terminated its Phase II study of the investigational monoclonal antibody simtuzumab in patients with idiopathic pulmonary fibrosis (IPF) due to lack of efficacy, Phase II studies of simtuzumab are ongoing in patients with non-alcoholic steatohepatitis (NASH) and primary sclerosing cholangitis (PSC)
The inhibition of these deleterious AT 1 receptor-mediated effects through ACE inhibitors or Ang receptor blockers (and more recently the direct renin inhibitor aliskiren) largely explains as to why the two former classes of antihypertensive drugs have become the gold standard of antihypertensive therapy
This disparity is partly due to the high costs and the ongoing debate about the long-term benefits and risks of using these drugs solely for weight loss
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