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The honest answer is: it's more interesting than most peptides in this space, the mechanism is real, there's some legitimate clinical evidence and there are also significant gaps in the data that the internet tends to paper over
As a proxy for heavy smoking (binary variable), we used diagnosis codes related to lung diseases highly associated with tobacco exposure along with diagnosis codes related to nicotine or tobacco, previous use of medications for the treatment of tobacco dependence, and initiation of drugs for obstructive airway disease after the age of 40
