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The results of a recent insightful study implicate the transcriptional control of the Nrf2 gene as a determinant of Nrf2 activity ( K-Ras activates Nrf2 transcription through the Mek-Erk-Jun signaling pathway and reduces the ROS levels in primary fibroblasts

Specifically, simulations suggest that blood Cys and GSH are reduced by 68.7% and 74.1% respectively, whereas cytosolic Cys and GSH are reduced by 81.2% and 64.6% respectively

10.1016/j.chom.2023.01.001 179 XuJ.LodgeT.KingdonC.StrongJ

Biomolecules 10 , 766 (2020)

The ASD group exhibited significantly higher scores on three of the four subscales of AASP (Low Registration, Sensory Sensitivity, and Sensation Avoiding), and significantly lower scores on the remaining subscale (Sensation Seeking)