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Tirzepatide potently activates the GLP-1R signalling pathway to stimulate glucose-dependent insulin secretion through activity at the GIP receptor (GIPR) or the GLP-1R
C., & Zhang, X
FDA Approval: Expected mid-to-late 2026 or 2027
Monitor blood glucose levels more frequently, check ketones if advised by your healthcare team, and consider temporarily adjusting other diabetes medications (particularly insulin, metformin or SGLT2 inhibitors) after seeking clinical advice if you're unable to eat or drink normally
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