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We then performed ChIP analysis and confirmed the recruitment of TR to the super-enhancer region containing two putative TR binding sites (Fig

1 Weight loss is thought to be promoted by decreased energy intake via two main mechanisms: 1) delay of gastric emptying via inhibition of peristalsis of the stomach while simultaneously increasing tonic contraction of the pyloric region and 2) suppression of appetite via central mechanisms

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Metabolic adaptation during GLP-1 therapy is less severe than with traditional dieting, which is one of the major advantages of GLP-1 medications

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