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MOTS-c activates AMPK, one of the same pathways exercise activates, which earned it the exercise mimetic label
Cecal mass did not significantly differ between groups (Supplementary Table S2)
Selectivity was reported against COMT and against the SAM-dependent DNA and protein methyltransferases DNMT1 and PRMT3
Research indicates it reduces pro-inflammatory cytokines like TNF-alpha, IL-6, and IL-1 beta, without broadly suppressing immune function the way corticosteroids do
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