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This policy ensures patients can explore treatment options with confidence, knowing they will not incur unnecessary costs if GLP-1 therapy is not suitable

It is found throughout the body, with particularly high concentrations in tissues with greater energy demands, including skeletal muscle, the heart and the liver

In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation

When ROS levels exceed those of antioxidant defenses, there is an aberrant increase in free radical generation resulting in mitochondrial damage and leading to oxidative stress and subsequently this increased stress can reduce ETC activity (Figure 2)