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Thus, the transient nature of estrogen elevations in female rats may limit estrogens facilitatory effects on GLP-1 signaling, potentially explaining the more robust disruption of alcohol discrimination observed in males

Ania Jastreboff, Professor of Medicine and Pediatrics at Yale School of Medicine, Director of the Yale Obesity Research Center, and the lead investigator of TRIUMPH-1, said the results showed "clear improvements in assessed cardiometabolic health measures" alongside the weight reduction

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