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Although skeletal effects are beneficial in preclinical investigations, clinical evidence on fracture risk is still uncertain

The core principle is chemical: copper is a redox-active metal, and pairing it carelessly with strong acids or potent oxidizers/reducers in the same layer can destabilize one or both ingredients and increase irritation

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When these ingredients come into contact with the skin, they can cause irritation or allergic reaction that can lead to the darkening of the skin

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