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Combined with the above-described studies, it is clear that GLP-1R agonists reduced inflammation, oxidative stress, mitochondrial dysfunction, and matrix remodelling to improve neuron functions in DPN ( Figure 1 )

Abstract Glucagon-like peptide-1 receptor agonists (GLP-1RAs) and sodium-glucose cotransporter-2 inhibitors (SGLT2i) have profoundly reshaped the therapeutic landscape of type 2 diabetes mellitus (T2DM)

Several clinical studies have found that GSH consumption exists in the blood of patients with myocardial infarction and the left ventricle of patients with heart failure [8, 38, 39]