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Fe 3+ subsequently binds to transferrin (TF) or lactoferrin (LF) to form a TFFe 3+ complex, which is then recognized and internalized by transferrin receptor 1 (TFR1) on the cell surface (Zhao et al., 2025b)
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22 In tablet form, entacapone, a well-established catechol-O-methyl transferase (COMT) enzyme inhibitor, has shown to increase the bioavailability of levodopa by extending its half-life
The vote also shows that a majority of the assembled committee accepted a clinical-need argument despite FDA staffs objections
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