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dNP2 is a bloodbrain barrier-permeable peptide enabling ctCTLA-4 protein delivery to ameliorate experimental autoimmune encephalomyelitis

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2320-C HEPATOCYTE DEPLETION OF ERK5 IMPAIRS THE RESPONSE TO LIPOTOXIC OXIDATIVE STRESS RESULTING IN DEFECTIVE INSULIN RECEPTOR SIGNALING Alessio Menconi 1 , Giovanni Di Maira 1 , Giulia Lori 1 , Nadia Navari 1 , Maria Letizia Taddei 1 , Salvatore Petta 2 , Rosaria Maria Pipitone 3 , Claudia Campani 4 , Cathy Tournier 5 , Elisabetta Rovida 1 and Fabio Marra 1 , (1)University of Florence, (2)Sezione Di Gastroenterologia, Dipartimento Promozione Della Salute, Materno-Infantile, Di Medicina Interna e Specialistica Di Eccellenza G

The peptide derived from gastric juice, works by interacting with the bodys natural healing processes to promote tissue repair and reduce inflammation

Cystobactamid 507: concise synthesis, mode of action, and optimization toward more potent antibiotics