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That said, as always, the key question is translatability

This gradual reduction helps the body adjust and allows the adrenal glands to resume their normal function

Excess weight promotes the development of a wide range of pathologies (insulin resistance, hypertension, chronic inflammation, dyslipidemia), which increase the risk of complications such as type 2 diabetes, cardiovascular disease, hepatic steatosis, several types of cancer and reduce life expectancy

Sequences for MIN6B1 were ON-TARGET plus Non-targeting Control Pool and ON-TARGET plus Mouse Arrb1 and Arrb2 SMARTpools (Dharmacon)