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Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu

Even after 12 months post-injury or surgical intervention, the tissue still lacks the biomechanical and ultrastructural characteristics it had prior to the injury (Fox et al

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Chen L et al

However, concerns about the possible deleterious consequences of such a dosage regimen still remain given that plasma concentrations of trimethylamine-N-oxide were continually rising and approximately doubled in a two-week period