This may be due to the existence of an intact IGF1R in both WT and knockin mice as well as effects from both ligands, insulin and IGF-1, which could at least partially compensate for their downstream signaling effects

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Thanks for being so sweet
Ding M, Zong Q, Zhang D, Ullah I, Zhang X, Liang W, Li X, Bulatov E, Yuan Y
Metabolic Impact: GH elevation may affect insulin sensitivity and disrupt glucose control