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B12 shots bypass GI absorption problems and deliver methylcobalamin (the active form) directly to your cells, making them far superior to oral B12 if you have any digestive issues or take acid-blocking medications
NNMT expression increases significantly with obesity and aging, particularly in white adipose tissue and skeletal muscle
Is it time for vitamin B-12 fortification
Thankfully, the risk of B12 side effects is low
For deficiency without neurological involvement or for borderline levels, oral supplementation with high-dose cyanocobalamin (1000-2000 mcg daily) is often effective, as approximately 1% of an oral dose is absorbed through passive diffusion even in the absence of intrinsic factor
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