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doi: 10.1073/pnas.1301816110 39
PubMed PMID: 36272651
doi:10.1016/0003-9861(92)90035-U
One such agent is Olorofim, a dihydroorotate dehydrogenase inhibitor currently in advanced clinical development, which impairs mitochondrial pyrimidine biosynthesis, leading to defective DNA synthesis and subsequent fungal cell death (Oliver et al., 2016)
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