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As a potent inducer of HSF activation, AA upregulates HSF activity and subsequently induces HSP accumulation, ultimately enhancing cellular thermotolerance (Jurivich et al., 1994
Most importantly, they demonstrate efficacy against schistosome infections in mice, meeting the criteria for lead progression indicated by WHO, and outperform the previously reported efficacy of praziquantel against juvenile worms 13
The weight reduction occurred gradually over five months, bringing animals back to a healthy weight
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