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Landucci G, Frontespezi S

Until now, the most effective GLP-1 weight loss treatments have mainly been weekly injections, which can put some patients off due to needle anxiety, inconvenience or stigma

The primary endpoint was major adverse cardiovascular events (MACE), defined as cardiovascular death, nonfatal heart attack, or nonfatal stroke

These include hypothalamic centers (PVN, dorsomedial nucleus [DMN], arcuate nucleus [ARC]), dopaminergic pathways (nucleus accumbens [NAc], substantia nigra [SNc], ventral tegmental area [VTA]), and brainstem nuclei (parabrachial nucleus [PBN], nucleus of the solitary tract [NTS], DMV, AP) 43