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MT1 has enhanced half-life and increased affinity for the melanocortin receptor 1 (MC1R), which regulates melanogenesis
These effects accelerate wound closure and strengthen the structural integrity of repaired tissue 1,2
7 weeks and lost 14lbs
Unlike semaglutide which solely activates GLP-1R (one of the three pivotal receptors regulating glucose homeostasis), tirzepatide also activates glucose-dependent insulinotropic polypeptide (GIP) receptor (GIPR) to enhance metabolic benefits with reduced side-effects 5
See primers in Table S8
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