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J Clin Invest 127(1):2432 Ohta S, Misawa A, Lefebvre V, Okano H, Kawakami Y, Toda M (2013) Sox6 up-regulation by macrophage migration inhibitory factor promotes survival and maintenance of mouse neural stem/progenitor cells

PMID 30780817

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While the prescribing information for GLP-1 medications does not specifically list Crohn's disease as a contraindication, the Summary of Product Characteristics (SmPC) for these medicines does advise caution in patients with gastrointestinal disease and states they are not recommended in severe gastrointestinal disease

La eficacia de Rybelsus es comparable pero generalmente ligeramente menor que la de la semaglutida inyectable a dosis equivalentes, debido a la menor biodisponibilidad de la formulacin oral (aproximadamente 1% comparado con la inyeccin subcutnea)