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These pathways and signaling pathways can promote BAT heat production
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2d), which can ensure the entire filling of the defect and maintain an appropriate microenvironment for cartilage regeneration 35
Increased oxidative stress, inflammation and lipotoxicity associated with hyperglycaemia and insulin resistance potentially impair vascular endothelial function and increase endothelial permeability, leading to the penetration of glycated and oxidized low-density lipoprotein (LDL) cholesterol into the endothelium, i.e., initiation of atherosclerosis
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