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Another strategy requires adrenal synthesis and supply of dehydroepiandrosterone (DHEA) and its sulfate (DHEA-S) which are converted to 4 -androstenedione (AD) by 3-hydroxysteroid dehydrogenase/isomerase (HSD3B1) in PCa (25, 26)
B12 is an essential nutrient, and its deficiency is common, especially among individuals following restricted diets like vegetarianism or veganism, pregnant or breastfeeding women, older adults, those who have undergone gastrointestinal surgery or have gastrointestinal disorders, and people with an autoimmune condition known as pernicious anaemia
Toxicol Pathol 43: 1004-1014, 2015
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Look for HPLC-MS verification showing greater than 98% purity (preferably 99%+) and endotoxin testing confirming bacterial contamination levels below safe thresholds
