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maintenance treatments or lifestyle changes are needed to sustain results

British Journal of Pharmacology / NIHMS PMC (2008) 6

Nrf2-dependent upregulation of HO-1 in curcumin-treated renal tubular epithelial cells challenged with high glucose concentrations was shown to prevent phenotype changes resembling fibrosis and known to occur at an early stage of diabetic renal injury (23)

Concentration challenges : Effective transdermal delivery requires high concentration gradients to drive absorption

Even the milder wrinkle creams still contain irritants, detergents, and polymeric substances that inflame, swell, or mechanically tighten the skin