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The most common gastrointestinal side effects include nausea (affecting 1/10 patients), diarrhoea, constipation, abdominal pain, and vomiting
By blocking NNMT, it prevents the methylation and degradation of nicotinamide, increasing the substrate available for NAD+ synthesis
Participants who took a placebo and received the same lifestyle interventions lost only 3 per cent of their body weight
10.1016/j.clinme.2025.100298 Clin Med
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