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& Parthasarathy, S
For 5-amino-1MQ specifically: Preclinical studies have not prominently described heart rate elevation as a dominant signal The mechanism (NNMT inhibition, NAD+ preservation) does not have the same direct cardiac implications as nuclear receptor agonism Human cardiovascular data at clinically relevant exposures are limited For physicians, the current evidence base does not support a major cardiovascular safety flag, but the limited human dataset means confident statements are premature
Description For use in Vitamin B-12 deficiency associated with cobalt deficiency in cattle and sheep and for Vitamin B-12 deficiency associated with inadequate Vitamin B-12 intake or intestinal malabsorption in swine and horses
MMA rises when cells dont have enough B12 to work with, so a normal serum B12 next to a high MMA can still point toward a real deficiency
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