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These observations seem to be associated with the inhibition of Na + /H + exchanger 3 (NHE3) in the proximal tubules
The absolute 3.3-point weight gap over a shorter window (48 vs 72 weeks) suggests retatrutide reaches maximum plateau faster and further
It is often studied alongside other incretin mimetics, such as GLP-2 , to compare signaling effects on metabolic function, insulin pathways, and appetite control
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PMCID: PMC12107490
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