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The adaptation time differs between individuals, but digestion stabilizes as treatment progresses

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Byer SJ, Eckert JM, Brossier NM, Clodfelder-Miller BJ, Turk AN, Carroll AJ, et al

When permeabilised INS-1 cells, perfused with an elevated fixed concentration of Ca 2+ and ATP, were exposed to a high concentration of glucose, insulin secretion was stimulated, accompanied by an increased intracellular glutamate concentration [67]