There is currently no effective cure, but the condition can be effectively managed through lifestyle changes, medications, and sometimes insulin therapy
Prescher, N., Hansch, S., Knobbe-Thomsen, C
Extensive preclinical research shows it influences collagen synthesis, antioxidant defense, and tissue regeneration in cell and animal models
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Moreover, the gene set enrichment analysis (GSEA) of the P4HA1 signature of HFD/LFD and SEMA/HFD comparisons displayed a statistical significant difference in NES related to peptidyl proline dioxygenase activity, in protein hydroxylation and in collagen fibril organization corroborating SEMA role in counteracting stroma development (Fig