Individuals with one or two copies of the genetic variation and low activity of the MTHFR enzyme may present with elevated homocysteine levels, which have been associated with inflammation, heart disease, pregnancy complications, and even miscarriages
However, individual assessment is essential, as gastrointestinal side effects may overlap with post-surgical digestive changes
On the other hand, RWE lacks the ability to establish causality by minimising confounding effects which is a key strength of randomised clinical trials (RCTs)
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Weve seen a gradual increase in patients with the problem over the past year as the popularity of GLP-1 drugs has soared